Fresh analysis reveals that patients who come off blockbuster slimming jabs like semaglutide or tirzepatide can put back on reduced body mass at a significantly accelerated pace than those who halt conventional lifestyle regimens.
Published data in a major medical journal shows that while obese people frequently drop a large proportion of their body weight while using the jabs, the mass comes back at an estimated rate of 0.8 kg per month once they quit.
"Users purchasing such drugs need to be informed of the danger of fast rebound weight gain when the medication is stopped," warns lead investigator Dr. Susan Jebb.
Such speed of regain implies a reversion to pre-treatment mass within about a year and a half.
Analyzing Therapies
The study, which reviewed 37 of studies involving thousands of participants, compared the outcomes of the injectable medications with conventional dieting.
Scientists emphasize that people who shed pounds through lifestyle changes alone typically have a less rapid weight regain—approximately 0.1 kg a month—once they finish.
The Reason for the Quick Rebound
Nutrition scientists propose the way of the injections accounts for the amplified rebound.
GLP-1 drugs mimic a body's own chemical called glucagon-like peptide-1, which helps regulate feelings of fullness.
"Long-term administration of the hormone levels far above than normal might result in the body to produce less of its endogenous hormone, and could lessen sensitivity to its actions," said Dr. Adam Collins, a nutrition researcher.
"Stopping of this medication results in appetite is no longer kept in check, making excessive eating much more probable."
A Chronic Disease?
Health authorities advise the injections for people with obesity-related medical conditions, accompanied by prescribed diet and exercise modifications.
A number of clinicians argue that, due to the high risk of relapse, the therapy is often long-term.
This opinion is echoed by drug manufacturers, who say that the findings "highlight the chronic character of obesity," akin to managing conditions like high blood pressure.
Patient Experiences
Individuals who have stopped the jabs report a intense return of hunger.
"I experienced something that goes on and you're instantly starving," described a patient.
The struggle is exacerbated if patients have not developed permanent dietary or behavioural changes during treatment.
Growing Adoption
Survey data indicate that millions of adults in the UK have tried weight-loss jabs in the last 12 months, with demand remaining high.
- Use is more common among females than men.
- The 40s and 50s age group shows the highest level of interest.
- Many obtain the medications through private prescriptions rather than public health services.
In conclusion, experts caution that while the jabs are powerful tools for shedding pounds, they are not a standalone cure and long-term success hinges on integrated behavioural management.
